Exenatide acetate is a synthetic GLP‑1 (glucagon-like peptide) analog consisting of 39 amino acids. Exenatide acetate is an incretin mimetic drug that can mimic the glucose-dependent insulin secretion enhancement and other antihyperglycemic effects of incretin.
Name: Exenatide
CAS No.: 141732-76-5
Peptide Sequence: H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
Molecular Formula: C184H282N50O60S
Molecular Weight: 4186.6
Appearance: White Lyophilized powder
The amino acid sequence of exenatide acetate partially overlaps with human GLP‑1. Exenatide acetate has been shown to bind and activate known human GLP-1 receptors in vitro. This means that glucose-dependent insulin synthesis and insulin secretion by pancreatic beta cells in vivo are increased by including cAMP (cyclic adenosine monophosphate) or other intracellular signaling mechanisms.
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