DSIP

DSIP Structure

Name: DSIP; Emideltide; Delta-Sleep Inducing Peptide
CAS No.: 62568-57-4
Peptide Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Molecular Formula: C35H48N10O15
Molecular Weight: 848.814
Appearance: White Lyophilized powder

What Is DSIP (Delta Sleep-Inducing Peptide)?

Delta sleep-inducing peptide (DSIP) is a short peptide of natural origin. It gains its name from its ability to cause sleep in rabbits and from the fact that it was first isolated in 1977 from the brains of rats during slow-wave sleep. The peptide, however, has a number of physiologic and endocrine roles that are slowly being uncovered as it gains interest among researchers. Right now, it is known that DSIP can alter corticotropin levels, inhibit somatostatin secretion, limit stress, normalize blood pressure, alter sleep patterns, and alter pain perception. It may also have future applications in cancer treatment, depression, and the prevention of free radical damage.

The Relationship of DSIP to Sleep

Despite its name, the connection between DSIP and sleep has been difficult to pin down.
Following the initial study in rabbits, DSIlP has undergone extensive investigation to determine itseffects on sleep. Unfortunately, a pattern has been difficult to isolate. In some studies, DSIPpromoted slow-wave sleep and suppressed paradoxical sleep. In other studies, DSIP has had noimpact on sleep at all. In one study, DSIP was found to cause arousal during the first hour of sleepfollowed by sedation starting in the second hour of sleep/1. Overall, this study suggested thatDSIP helps to normalize sleep and regulate dysfunction in sleep cycles, effects which tend to becorroborated by other research.

Perhaps the most significant sleep research involving DSIP has been performed in the setting ofchronic insomnia. In this particular example, the peptide appears to improve sleep enough tomatch that of normal controls/2.These findings are reflected in other studies showing that DSIPimproves sleep structure and reduces sleep latency in chronic insomnia.Overall,
polysomnographic studies indicate higher sleep efficiency with DSIP that, while statisticallysignificant, is still relatively weakl3].

Despite the contradictions in the research, it is almost impossible to deny that DSIP is in someway related to sleep onset.Research in human subjects has uncovered a number of subjectivemeasures indicating that DSIP promotes sleep.For instance, DSIP produces feelings of
sleepiness, increases sleep time by 59% compared to placebo, and shortens sleep onset. Thesesubjective findings, however, are almost perfectly contradicted by EEG analyses that show noobvious sedation

. The problem, however, may by with current testing methodologies as manyEEG measures of sedation are based on pharmacologic sedation and not natural sedation.At thevery least, DSlP offers a new and useful tool for reevaluating how we measure sleep in the laboratory. It may help scientists to develop a more thorough understanding of human sleep, aphysiologic function that is still shrouded in a great deal of mystery despite more than a century ofdedicated research.

DSIP Research and Chronic Pain

Analgesic control can be difficult in the setting of chronic pain. Current medications, such as NSAIDs and opiates, while effective in the short term, can have serious side effects when used fortoo long. Current analgesics are best suited to the short-term treatment of pain, so researchershave sought an alternative for treating chronic pain syndromes. A small pre-clinical trial in humanshas found that DSIP can significantly reduce pain perception and improve mood.This same studyfound that DSlP may be useful in patients with a physiologic dependence on other pain medications as it helps to reduce withdrawal symptoms and the pain rebound that often occursfollowing cessation of long-term analgesic therapy.

Research in rats suggests that DSIP acts on central opioid receptors to produce its analgesiceffects. lt isn’t clear if these are direct or indirect effects, but the peptide produces a significantpain-relieving effect that is dose dependentl. There is no indication that DSIP produces the kindof dependency that opiate medications do despite the fact that both work on the same receptors inthe central nervous system.

DSIP Research and Metabolism

Research in rats indicates that DSIP alters the stress-induced metabolic disturbances that oftencause mitochondria to shift from oxygen-dependent respiration to oxygen-independent respiration.The latter is much less efficient and is associated with the production of toxic metabolic byproducts. The ability of DSIP to maintain oxidative phosphorylation, even in the setting ofhypoxia, could make the peptide a useful treatment in conditions like stroke and heart attack. Bypreserving normal mitochondrial function, DSIP could help to offset the metabolic damage causedby oxygen deprivation and protect tissue until proper blood flow can be reestablished.

These properties would make DSIP a very powerful antioxidant and one that works at the mostbasic level of free radical production.By preserving normal mitochondrial function, DSIP reducesthe production of free radicals.This may make it a potent anti-aging supplement, though muchmore research is required to understand the exact effects of the peptide.

Product use: This product is only for research chemicals.