Desmopressin

Desmopressin Structure

Name: Desmopressin (DDAVP)
CAS No.: 16789-98-3
Peptide Sequence: 3-Mercaptopropionyl-Tyr-Phe-Gln-Asn-Cys-Pro-D-Arg-Gly-NH2 cyclic (1→6) disulphide
Molecular Formula: C48H68N14O14S2
Molecular Weight: 1129.27
Appearance: White Lyophilized powder

Desmopressin Overview

Desmopressin acetate (DDAVP), which is the deamination of 1-cysteine and the replacement of 8-L-arginine with 8-D-arginine, also known as aminoarginine vasopressin, is a natural Structural analog of arginine vasopressin, a derivative of vasopressin, its antidiuretic effect is more powerful and durable than that of vasopressin, but it has no vasoconstriction effect and has few drug side effects. It is clinically used for congenital Or drug-induced platelet dysfunction, uremia, liver cirrhosis and unexplained bleeding time prolongation; can be used to control and prevent bleeding during minor surgery; central diabetes insipidus, etc.

Pharmacological action

Desmopressin acetate contains desmopressin similar in structure to natural arginine vasopressin. It differs from arginine vasopressin mainly in the deamination of cysteine and the replacement of L-arginine with D-arginine. After these structural changes, the action time of clinical dose of desmopressin is prolonged without the side effects of pressurization. The results of some studies have shown that Micoagulation has a significant anti-enuresis effect, which may be because after taking the drug, the level of arginine vasopressin in the blood of children at night is increased, and then the urine is concentrated, the urine volume and intravascular pressure are reduced, and the bladder is reduced. The neck is lowered and the detrusor muscle contraction is reduced.